Lois takes Stewie’s sick new best friend to the hospital—and learns that he has a treatable cancer. But his parents won’t allow treatment on religious grounds, and Lois is aghast (to put it mildly). Meanwhile, Peter has a religious experience of his own.

At a Disabled Ladies’ Night at the Drunken Clam, Brian hits it off with a blind woman. She tells him that she hates dogs, but that’s not a problem until their relationship progresses to the point where he meets her sighted parents. Meanwhile, Lois replaces the stairs at the Griffin house after Stewie gets a [...]

Quagmire is the only guest at Meg’s 18th-birthday party and soon they hit if off—much to her parents’ distress, of course. Peter is especially miffed and won’t rest until he stops his Lothario neighbor from having his way with his daughter.

When Carter falls asleep at the wheel, Babs, Lois and Peter decide that it’s time for him to retire, so they head to Florida to check out senior communities. Carter isn’t exactly enthusiastic. R. Lee Ermey has a voice cameo as a drill sergeant and Mae Whitman as an overweight girl.

Feeling henpecked, Peter, Joe, Quagmire and Cleveland decide to take a road trip. Destination: New Orleans. But they get lost on the way and soon find themselves face-to-face with a small-town sheriff. So begins a Deep South adventure. Back in Quahog, Lois, Bonnie and the visiting Donna (voice of Sanaa Lathan) don’t miss their men [...]

Car trouble strands the Griffins in Amish country, where Meg hits it off with a local boy. But his stern father disapproves, so Peter must convince him that Meg won’t “corrupt” his son. Peter also introduces the townsfolk to rock and roll.

Lois cooks a big Thanksgiving meal and invites everyone over for dinner. Meanwhile, Joe is shocked when his MIA son (voice of Scott Grimes) returns from Iraq

Brian and Stewie travel back in time to the series’ pilot episode to change history. Then they do it again.

Ryan Reynolds (providing his own voice) visits Quahog and becomes obsessed with Peter. Meanwhile, Stewie steals the family car and goes for a joyride that proves to be less than joyful

Quagmire’s sister (voice of Kaitlin Olson) is little more than a punching bag for her abusive boyfriend, so Quagmire, Joe, Bonnie and the Griffins decide to do something about it.